How a specific protein regulates brain cell development and function
Regulation of hippocampal morphogenesis and homeostasis by the E3 ubiquitin ligase CRL5
This study is looking at how a specific protein helps brain cells grow and work properly, especially in an area important for memory, to see how problems in this process might relate to Alzheimer's disease, with the hope of finding new ways to improve brain health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10557808 on NIH RePORTER |
What this research studies
This research investigates how the E3 ubiquitin ligase CRL5 influences the development and maintenance of brain cells, particularly in the hippocampus, which is crucial for memory and learning. By understanding the signaling pathways that guide neuron migration and integration, the study aims to uncover how disruptions in these processes may contribute to conditions like Alzheimer's disease. The approach involves examining the mechanisms of protein degradation that control these signaling pathways, which could lead to new insights into brain health and disease. Patients may benefit from advancements in understanding and potentially treating neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing neurodegenerative disorders.
Not a fit: Patients with non-neurological conditions or those not affected by neurodegenerative diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating Alzheimer's disease and other neurodegenerative conditions.
How similar studies have performed: Previous research has shown that targeting protein degradation pathways can lead to significant advancements in understanding and treating neurodegenerative diseases, indicating a promising approach.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Simo, Sergi — University of California at Davis
- Study coordinator: Simo, Sergi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.