How a specific protein pump affects cell signaling and function
Official title: Molecular Mechanisms of Cellular Signaling by the Proton Pumping Vacuolar ATPase
Funded at State University New York Stony Brook · NIH-11020261 · Data updated 2026-11-12
This study is looking at a protein called V-ATPase that helps control the acidity inside our cells, and it's trying to find out how changes in this protein might be linked to diseases like cancer and brain disorders, which could help develop new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $392,024 |
| NIH project number | 1R35GM157043-01 |
| Project ID | NIH-11020261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancer, neurodegenerative diseases, or infectious diseases that may be linked to cellular signaling dysfunction.
✕Less likely to help
Patients with conditions unrelated to cellular signaling or those not experiencing issues related to pH regulation and autophagy may not benefit from this research.
What this research studies
This research investigates the role of the vacuolar ATPase (V-ATPase), a protein that helps regulate the acidity of cell compartments, in various diseases such as cancer and neurodegenerative disorders. By using advanced techniques like cryo-electron microscopy and biochemical assays, the researchers aim to understand how changes in the V-ATPase's structure and function influence cellular signaling and processes. Patients may benefit from insights gained into how this protein affects disease mechanisms, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments targeting the V-ATPase to improve outcomes for patients with cancer and other related diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of V-ATPase in cellular processes, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Sharma, Stuti — State University New York Stony Brook
- Study coordinator: Sharma, Stuti
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.