How a specific protein modification affects lung inflammation
ISGylation regulates lung endothelial inflammation
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10815727
This study is looking at how a specific change in a protein might help control inflammation in the lungs, which is important for people with conditions like acute respiratory distress syndrome (ARDS) and sepsis, and it hopes to find new ways to treat these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10815727 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein modification called ISGylation in regulating inflammation in lung endothelial cells, which are crucial for maintaining lung function. The study focuses on how this modification affects the activity of a key protein involved in inflammation, known as NF-κB, and aims to uncover the molecular mechanisms behind this process. By understanding these mechanisms, the research seeks to identify potential therapeutic targets for conditions like acute respiratory distress syndrome (ARDS) and sepsis, which are characterized by excessive lung inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from acute respiratory distress syndrome (ARDS) or other conditions involving lung inflammation.
Not a fit: Patients with chronic lung diseases that do not involve acute inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce lung inflammation and improve outcomes for patients with severe respiratory conditions.
How similar studies have performed: Other research has shown promising results in targeting inflammatory pathways in lung diseases, suggesting that this approach could be effective.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHAO, YUTONG — OHIO STATE UNIVERSITY
- Study coordinator: ZHAO, YUTONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disorder