How a specific protein modification affects learning and memory processes
Understanding how post-translational palmitoylation influences in vivo molecular and circuit dynamics during learning
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-10834083
This study looks at how a special process in the brain helps young zebrafish learn to ignore unimportant things, and it could help us understand more about learning and memory issues in people with conditions like schizophrenia and autism, potentially leading to new treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10834083 on ClinicalTrials.gov |
What this research studies
This research investigates the role of post-translational palmitoylation in the process of habituation learning, which is essential for filtering out irrelevant stimuli. By using larval zebrafish as a model, the study explores how a specific enzyme, Hip14, modifies a channel protein to influence learning behaviors. The findings aim to bridge gaps in understanding how molecular changes affect cognitive functions, particularly in relation to disorders like schizophrenia and autism. Patients may benefit from insights that could lead to new therapeutic strategies for cognitive impairments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cognitive disorders such as schizophrenia, autism spectrum disorders, or Huntington’s disease.
Not a fit: Patients with cognitive impairments not related to the mechanisms of habituation learning may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cognitive disorders by enhancing our understanding of learning mechanisms.
How similar studies have performed: While the specific approach of studying palmitoylation in habituation learning is novel, related research has shown success in understanding cognitive processes through molecular mechanisms.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NELSON, JESSICA C — UNIVERSITY OF COLORADO DENVER
- Study coordinator: NELSON, JESSICA C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.