How a specific protein influences blood stem cell health in older adults
Extrinsic regulation of primitive, myeloid-biased hematopoietic stem cells by Semaphorin 4a
This study is looking at how a protein called Semaphorin 4a affects certain blood stem cells in the bone marrow, especially as we age or face stress, to find new ways to help our bodies make healthy blood cells and prevent them from getting worn out.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10994640 on NIH RePORTER |
What this research studies
This research investigates the role of Semaphorin 4a in regulating myeloid-biased hematopoietic stem cells (myHSC) within the bone marrow, particularly in the context of aging and stress. By understanding how this protein affects the quiescence and self-renewal of these stem cells, the study aims to identify new pathways that could enhance blood cell regeneration. The research employs pre-clinical models to test the therapeutic potential of manipulating these pathways to protect against stem cell exhaustion and improve overall blood health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related decline in blood cell production or those with conditions affecting hematopoietic stem cells.
Not a fit: Patients who are younger or do not have issues related to blood cell production or hematopoietic stem cell function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance blood cell regeneration in older adults, improving their health and resilience against age-related blood disorders.
How similar studies have performed: Other research has shown promising results in manipulating signaling pathways to enhance stem cell function, suggesting that this approach may yield significant advancements.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Silberstein, Lev — Fred Hutchinson Cancer Center
- Study coordinator: Silberstein, Lev
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.