How a specific protein in the kidney regulates salt and blood pressure
Official title: ATP1A1-dependent Regulation of Sodium Handling by the Renal Proximal Tubule: Mechanism and Implications in Salt-Sensitivity
Funded at Marshall University · NIH-10883741 · Data updated 2026-11-12
This study is looking at a protein called ATP1A1 in the kidneys to see how it helps control sodium levels and blood pressure, which could be helpful for people who are sensitive to salt and have high blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marshall University NIH-funded |
| Lab location | 1 site (Huntington, UNITED STATES) |
| Project start | August 24, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $328,097 |
| NIH project number | 5R01DK129937-04 |
| Project ID | NIH-10883741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with hypertension or salt-sensitive conditions.
✕Less likely to help
Patients without issues related to blood pressure or sodium handling may not benefit from this research.
What this research studies
This research investigates the role of the ATP1A1 protein in the kidneys, focusing on how it manages sodium levels and influences blood pressure. The study explores two functions of ATP1A1: one that helps the kidneys retain sodium and another that reduces sodium uptake. By understanding these mechanisms, researchers aim to uncover how they affect salt sensitivity and blood pressure control in patients. The approach involves detailed biochemical analyses and cellular experiments to elucidate the dual roles of ATP1A1 in renal function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for managing blood pressure and salt sensitivity in patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of ATP1A1 in other contexts, suggesting potential for success in this area.
Where this research is happening
-
Marshall University
Huntington, United States Active
Researchers
- Principal investigator: Pierre, Sandrine V — Marshall University
- Study coordinator: Pierre, Sandrine V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.