How a specific protein helps protect neurons during viral infections
Official title: RIPK3-dependent suppression of excitotoxicity during neuronal flavivirus infection
Funded at Rutgers, the State Univ of N.j. · NIH-10742250 · Data updated 2026-11-12
This study is looking at how a protein called RIPK3 helps protect nerve cells during infections like the Zika virus, with the hope of finding ways to keep these cells healthy and functioning well when faced with viruses.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | August 11, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $431,750 |
| NIH project number | 1R21NS130282-01A1 |
| Project ID | NIH-10742250 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by flavivirus infections, particularly those experiencing neurological symptoms.
✕Less likely to help
Patients with non-viral neurological conditions or those not affected by flavivirus infections may not benefit from this research.
What this research studies
This research investigates how the protein RIPK3 influences the immune response of neurons during flavivirus infections, such as Zika virus. It aims to understand how RIPK3 activation can lead to protective mechanisms that prevent cell death and support the expression of genes important for neuronal function. By studying neuronal cultures and animal models, the research explores the relationship between RIPK3 and neurotransmitter regulation, which could reveal new insights into neuronal health during viral infections.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance neuronal survival and function during viral infections.
How similar studies have gone: Other research has shown promising results in understanding the role of immune responses in neuronal health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Daniels, Brian — Rutgers, the State Univ of N.j.
- Study coordinator: Daniels, Brian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.