How a specific protein complex affects brain cell development
Gene regulatory mechanisms governed by the ASXL1/HCF1/OGT complex during neurogenesis
['FUNDING_OTHER'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-10878880
This study is looking at how a protein called HCFC1 affects brain development and how changes in this protein might cause brain disorders, using zebrafish to help understand these processes better, with the hope of finding new treatments for people with these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10878880 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the HCFC1 protein in brain development, particularly how mutations in this protein can lead to various neurological disorders. By studying zebrafish models, researchers are examining how HCFC1 influences the proliferation of neural precursor cells, which are crucial for forming different types of brain cells. The study employs advanced techniques like immunohistochemistry and transcriptomics to analyze cell behavior and gene expression changes in response to mutations. The ultimate goal is to understand the underlying mechanisms that could lead to new treatments for brain disorders associated with HCFC1 mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital anomalies or neurological disorders associated with HCFC1 mutations.
Not a fit: Patients without mutations in the HCFC1 gene or those not affected by related neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological disorders linked to HCFC1 mutations.
How similar studies have performed: Previous research has shown promising results in understanding the role of similar protein complexes in brain development, indicating potential for success in this area.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CASTRO, VICTORIA L — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: CASTRO, VICTORIA L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.