How a specific protein affects the structure of cells during Chlamydia infections
Official title: Regulation of cytoskeletal reorganization by a single effector during Chlamydia infection
Funded at Thomas Jefferson University · NIH-11037588 · Data updated 2026-11-12
This study is looking at how the Chlamydia bacteria use a special protein to help them survive and grow inside our cells, with the goal of finding new ways to treat or prevent Chlamydia infections that can affect reproductive health.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $75,660 |
| NIH project number | 1R03AI187994-01 |
| Project ID | NIH-11037588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with Chlamydia trachomatis infections or are at high risk for such infections.
✕Less likely to help
Patients who are not infected with Chlamydia or those who have already undergone successful treatment may not benefit from this research.
What this research studies
This research investigates how the bacterium Chlamydia trachomatis manipulates host cell structures to survive and cause disease. It focuses on a specific protein, InaC/CT813, which plays a crucial role in forming cellular scaffolds that protect the bacteria and facilitate its growth. By understanding these interactions, the research aims to uncover potential targets for new treatments or preventive measures against Chlamydia infections, which can lead to serious reproductive health issues. The study employs advanced techniques to analyze the cellular changes induced by the infection.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Chlamydia infections, potentially reducing rates of infertility and other reproductive health complications.
How similar studies have gone: Previous research has shown success in understanding bacterial manipulation of host cell processes, indicating that this approach could yield valuable insights.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Paumet, Fabienne Michelle — Thomas Jefferson University
- Study coordinator: Paumet, Fabienne Michelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.