How a specific protein affects stroke severity in HIV patients
Official title: CCL2/CCR2 modulates HIV-associated ischemic stroke by regulating blood brain barrier monocyte recruitment
Funded at University of Miami School of Medicine · NIH-11085498 · Data updated 2026-11-12
This study is looking at how a specific protein and its receptor might make strokes worse for people living with HIV, with the goal of finding new ways to help them recover better after a stroke.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $422,125 |
| NIH project number | 1R21NS141704-01 |
| Project ID | NIH-11085498 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are at risk of ischemic stroke.
✕Less likely to help
Patients who do not have HIV or those who have not experienced a stroke may not benefit from this research.
What this research studies
This research investigates the role of the CCL2 protein and its receptor CCR2 in increasing the risk and severity of ischemic stroke in individuals with HIV. The study focuses on how these proteins influence the recruitment of immune cells to the brain and the disruption of the blood-brain barrier during a stroke. By understanding these mechanisms, the researchers aim to identify potential therapeutic targets that could improve recovery outcomes for HIV-infected patients who suffer from strokes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce stroke severity and improve recovery for HIV patients.
How similar studies have gone: Previous research has shown that targeting inflammatory pathways can improve outcomes in stroke patients, suggesting potential success for this approach.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Torices, Silvia — University of Miami School of Medicine
- Study coordinator: Torices, Silvia
Related research
Other NIH-funded projects on the same topics.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
-
Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
-
Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
-
Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.