How a specific protein affects stroke severity in HIV patients
CCL2/CCR2 modulates HIV-associated ischemic stroke by regulating blood brain barrier monocyte recruitment
This study is looking at how a specific protein and its receptor might make strokes worse for people living with HIV, with the goal of finding new ways to help them recover better after a stroke.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11085498 on NIH RePORTER |
What this research studies
This research investigates the role of the CCL2 protein and its receptor CCR2 in increasing the risk and severity of ischemic stroke in individuals with HIV. The study focuses on how these proteins influence the recruitment of immune cells to the brain and the disruption of the blood-brain barrier during a stroke. By understanding these mechanisms, the researchers aim to identify potential therapeutic targets that could improve recovery outcomes for HIV-infected patients who suffer from strokes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are at risk of ischemic stroke.
Not a fit: Patients who do not have HIV or those who have not experienced a stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce stroke severity and improve recovery for HIV patients.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can improve outcomes in stroke patients, suggesting potential success for this approach.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Torices, Silvia — University of Miami School of Medicine
- Study coordinator: Torices, Silvia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.