How a specific protein affects nervous system health and function
Official title: Regulation of nervous system health and function by the E3 ligase UBR-1
Funded at Seattle Children's Hospital · NIH-10996684 · Data updated 2026-11-12
This study is looking at a protein called UBR-1 to see how it helps keep our nervous system healthy, using tiny worms to learn more about how it affects movement and a key brain chemical called glutamate, which could help us understand nervous system disorders better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 2, 2024 |
| Project end | September 1, 2025 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32GM156113-01 |
| Project ID | NIH-10996684 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by neurological disorders, particularly those related to protein misregulation.
✕Less likely to help
Patients with neurological conditions unrelated to protein regulation may not benefit from this research.
What this research studies
This research investigates the role of the UBR-1 protein in maintaining the health and function of the nervous system using the model organism C. elegans. By employing advanced techniques like CRISPR, the study aims to understand how UBR-1 regulates locomotor behavior and the synthesis of glutamate, a crucial neurotransmitter. The research will involve genetic, behavioral, and protein expression studies to uncover the biochemical mechanisms behind UBR-1's function. Insights gained from this research could lead to a better understanding of nervous system disorders.
Why it matters
Potential benefit: If successful, this research could provide new insights into the treatment of neurological disorders related to protein regulation.
How similar studies have gone: While the specific approach using C. elegans and UBR-1 is novel, similar studies have shown success in understanding protein functions in neurological contexts.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Pak, Joseph — Seattle Children's Hospital
- Study coordinator: Pak, Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.