How a specific protein affects mitochondria and gene expression
Official title: Impact of a Histone H3K9 Methyltransferase on Mitochondria
Funded at University of Delaware · NIH-11138957 · Data updated 2026-11-12
This study is looking at a protein called SETDB1 to see how it affects cell function and energy production, which could help us understand its role in diseases like leukemia, using tiny worms as a model.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | June 17, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $155,559 |
| NIH project number | 1R03TR005626-01 |
| Project ID | NIH-11138957 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia or related rare diseases.
✕Less likely to help
Patients with conditions unrelated to the role of SETDB1 or mitochondrial dysfunction may not benefit from this research.
What this research studies
This research investigates the role of the histone methyltransferase SETDB1 in both the nucleus and cytoplasm, particularly its impact on mitochondria and gene expression. By studying a model organism, C. elegans, the researchers aim to understand how alterations in SETDB1 activity are linked to various diseases, including acute myeloid leukemia. The study employs advanced imaging techniques to visualize the localization and function of SETDB1 and its homolog MET-2, focusing on mitochondrial morphology and cellular responses to specific compounds. This approach could reveal new insights into the cellular mechanisms underlying these diseases.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of disease mechanisms and potential new therapeutic targets for conditions like acute myeloid leukemia.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promising results in understanding the roles of histone modifications in disease.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Tanis, Jessica E — University of Delaware
- Study coordinator: Tanis, Jessica E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.