How a specific protein affects gene regulation and development
Official title: Non-canonical mechanisms of gene regulation by the histone demethylase KDM5
Funded at Albert Einstein College of Medicine · NIH-10933514 · Data updated 2026-11-12
This study is looking at how a group of proteins called KDM5 helps control gene activity in fruit flies, which could give us clues about important growth processes and diseases like cancer and intellectual disabilities, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $336,000 |
| NIH project number | 5R01GM150189-02 |
| Project ID | NIH-10933514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancers or genetic disorders linked to gene regulation abnormalities.
✕Less likely to help
Patients with conditions unrelated to gene regulation or those not affected by cancer or genetic disorders may not benefit from this research.
What this research studies
This research investigates the role of the KDM5 protein family in regulating gene expression, particularly focusing on mechanisms that do not involve its known enzymatic activity. Using the fruit fly Drosophila as a model organism, the study aims to uncover how KDM5 contributes to essential developmental processes and its implications in diseases like cancer and intellectual disabilities. By exploring the interactions of KDM5 with other protein complexes, the research seeks to define new pathways that could be targeted for therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatment strategies for cancers and genetic disorders.
How similar studies have gone: While the specific approach of investigating non-canonical functions of KDM5 is relatively novel, similar studies on gene regulation have shown promising results in understanding developmental processes and disease mechanisms.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Secombe, Julie — Albert Einstein College of Medicine
- Study coordinator: Secombe, Julie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.