How a specific protein affects cell death in the heart
The Deubiquitinase CYLD Controls Multiple Cell Death Pathways in the Heart
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11070331
This study is looking at how a protein called CYLD affects heart cells during injuries like heart attacks and heart failure, with the goal of finding new ways to protect these cells and improve heart health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11070331 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the CYLD protein in regulating different types of cell death in heart cells, particularly in the context of heart diseases like ischemia and heart failure. The study uses advanced mouse models to explore how manipulating CYLD levels can either protect or harm heart cells during injury. By understanding these mechanisms, the research aims to identify new therapeutic strategies to prevent heart cell death and improve heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with heart conditions such as ischemic heart disease or heart failure.
Not a fit: Patients with non-cardiac conditions or those whose heart issues are not related to cell death processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect heart cells from dying, potentially improving outcomes for patients with heart disease.
How similar studies have performed: Other research has shown promising results in targeting cell death pathways in heart disease, suggesting that this approach could be effective.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, QINGHANG — UNIVERSITY OF WASHINGTON
- Study coordinator: LIU, QINGHANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.