How a specific oral bacteria affects antiviral responses in the mouth
Official title: Regulation and Manipulation of Oral Type III Interferon Responses by Porphyromonas gingivalis
Funded at Research Inst Nationwide Children's Hosp · NIH-11005777 · Data updated 2026-11-12
This study is looking at how a specific bacteria in your mouth might affect your body's ability to fight off viral infections, with the hope of finding new ways to boost your immune response and improve oral health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $417,169 |
| NIH project number | 5R01DE031756-03 |
| Project ID | NIH-11005777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with periodontal disease or those experiencing oral dysbiosis.
✕Less likely to help
Patients without oral health issues or those not affected by viral infections may not benefit from this research.
What this research studies
This research investigates how Type III interferons, which are important for fighting viral infections, are regulated by the bacteria Porphyromonas gingivalis in the oral cavity. The study focuses on understanding how this bacteria can suppress the antiviral responses of oral epithelial cells, potentially leading to increased susceptibility to viral infections. By examining the interactions between these interferons and the bacteria, the research aims to uncover mechanisms that could improve antiviral immunity at the oral mucosal barrier. Patients may benefit from insights that could lead to new treatments for viral infections linked to oral health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing antiviral immunity in patients with oral health issues.
How similar studies have gone: Other research has shown that understanding the role of oral bacteria in immune responses can lead to significant advancements in antiviral therapies.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Bagaitkar, Juhi — Research Inst Nationwide Children's Hosp
- Study coordinator: Bagaitkar, Juhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.