How a specific molecule affects heart cell function related to irregular heartbeats
Official title: Regulation of cardiac small-conductance calcium-activated potassium channels by PIP2
Funded at University of California at Davis · NIH-10929368 · Data updated 2026-11-12
This study is looking at how a molecule called PIP2 affects certain channels in heart cells that help keep your heartbeat steady, with the goal of finding new ways to treat heart rhythm problems like atrial fibrillation.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $41,318 |
| NIH project number | 5F31HL170698-02 |
| Project ID | NIH-10929368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cardiac arrhythmias, particularly those experiencing atrial fibrillation.
✕Less likely to help
Patients with arrhythmias that are not related to SK channel dysfunction may not benefit from this research.
What this research studies
This research investigates the role of a molecule called phosphatidylinositol 4,5-bisphosphate (PIP2) in regulating small-conductance calcium-activated potassium channels (SK channels) in heart cells. These channels are crucial for maintaining normal heart rhythm, and their dysfunction can lead to serious conditions like atrial fibrillation. The study employs advanced techniques such as patch-clamp and super-resolution imaging to explore how PIP2 influences the behavior of these channels in cardiomyocytes. By understanding this relationship, the research aims to identify new therapeutic targets for treating cardiac arrhythmias.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from life-threatening heart rhythm disorders.
How similar studies have gone: Previous research has shown promise in targeting ion channels for arrhythmia treatment, suggesting that this approach could be a valuable addition to existing therapies.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Trinh, Pauline — University of California at Davis
- Study coordinator: Trinh, Pauline
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.