How a specific microRNA can improve the function of exhausted immune cells in cancer treatment
Official title: Epigenetic regulation of exhausted CD8 T cells via the miR-29a-TET2 axis
Funded at University of Miami School of Medicine · NIH-11123172 · Data updated 2026-11-12
This study is looking at how a tiny molecule called microRNA-29a can help tired immune cells called CD8 T cells work better, which could lead to better treatments for people dealing with chronic infections and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | June 21, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $451,004 |
| NIH project number | 5R01AI183292-02 |
| Project ID | NIH-11123172 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with chronic infections or cancers who are experiencing T cell exhaustion and have not responded well to current immunotherapies.
✕Less likely to help
Patients with conditions unrelated to T cell exhaustion or those who have not undergone immunotherapy may not benefit from this research.
What this research studies
This research investigates the role of microRNA-29a in enhancing the function of exhausted CD8 T cells, which are crucial for fighting chronic infections and cancer. By focusing on the epigenetic changes that occur in these immune cells, the study aims to develop strategies that can improve their ability to respond to immunotherapy. The researchers will explore how manipulating this microRNA can lead to better immune responses and potentially overcome resistance to existing treatments. Patients may benefit from improved therapies that enhance their immune system's ability to combat cancer and chronic infections.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies that provide long-lasting protection against cancer and chronic infections.
How similar studies have gone: While the specific approach of targeting microRNA-29a in T cell exhaustion is novel, similar strategies targeting epigenetic regulation in immune cells have shown promise in other studies.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Stelekati, Erietta — University of Miami School of Medicine
- Study coordinator: Stelekati, Erietta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.