How a specific microRNA affects cholesterol levels in the blood
Official title: Regulation of plasma LDL and HDL by microRNA-541-3p
Funded at NYU Long Island School of Medicine · NIH-11126850 · Data updated 2026-11-12
This study is looking at how a tiny molecule called microRNA-541-3p helps control cholesterol levels in the liver by affecting two important proteins, which could lead to new ways to manage cholesterol and improve heart health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | NYU Long Island School of Medicine NIH-funded |
| Lab location | 1 site (Mineola, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $631,876 |
| NIH project number | 5R01HL166214-03 |
| Project ID | NIH-11126850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with high LDL cholesterol and low HDL cholesterol levels, particularly those at risk for cardiovascular diseases.
✕Less likely to help
Patients with normal cholesterol levels or those whose cardiovascular issues are unrelated to cholesterol may not benefit from this research.
What this research studies
This research investigates the role of microRNA-541-3p in regulating cholesterol levels by influencing the secretion of two important proteins, ApoB and ApoA1, in liver cells. The study aims to understand the mechanisms by which this microRNA interacts with specific transcription factors to control these proteins' expression. By examining these interactions, the research seeks to uncover new insights into how cholesterol levels can be managed, potentially leading to better treatments for cardiovascular diseases. Patients may benefit from findings that could lead to novel therapeutic strategies targeting cholesterol regulation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help lower bad cholesterol and raise good cholesterol, reducing the risk of cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of microRNAs in cholesterol regulation, indicating that this approach has potential for success.
Where this research is happening
-
NYU Long Island School of Medicine
Mineola, United States Active
Researchers
- Principal investigator: Hussain, M Mahmood — NYU Long Island School of Medicine
- Study coordinator: Hussain, M Mahmood
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.