How a specific microorganism communicates and changes shape
Cell-cell signaling in archaea: How Haloferax volcanii talk to each other
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF PENNSYLVANIA · NIH-11063093
This study looks at how tiny microorganisms called Haloferax volcanii communicate with each other to change their shape and behavior, which could help us understand their role in our health and the human microbiome.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11063093 on ClinicalTrials.gov |
What this research studies
This research investigates the communication methods of the archaeon Haloferax volcanii, focusing on how these microorganisms signal each other to change shape and behavior. By studying the effects of a secreted signaling molecule known as Disk Forming Signal (DFS), the research aims to understand the implications of archaeal signaling in the human microbiome. The methodology includes culturing H. volcanii and observing changes in cell morphology and motility in response to conditioned media. This could provide insights into the role of archaea in human health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the role of archaea in the human microbiome and its potential health implications.
Not a fit: Patients who are not affected by microbiome-related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of the human microbiome and lead to new strategies for managing microbial-related health issues.
How similar studies have performed: While studies on bacterial signaling are well-established, research specifically focusing on archaeal signaling is relatively novel and has not been extensively tested.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHATTERJEE, PRIYANKA — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: CHATTERJEE, PRIYANKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.