How a specific lipid affects inflammation in the intestines
Official title: Prostaglandin D2 and its receptor CRTH2 regulate intestinal inflammation and homeostasis
Funded at University of Washington · NIH-10875441 · Data updated 2026-11-12
This study is looking at how a substance called prostaglandin D2 and its receptor help control inflammation in the intestines, especially when dealing with infections or injuries, to find new ways to support gut health for people with conditions like food allergies and parasitic infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $492,334 |
| NIH project number | 5R01DK134410-02 |
| Project ID | NIH-10875441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from food allergies or those experiencing intestinal inflammation.
✕Less likely to help
Patients with non-inflammatory gastrointestinal disorders or those without a history of food allergies may not benefit from this research.
What this research studies
This research investigates the role of prostaglandin D2 and its receptor CRTH2 in regulating inflammation and maintaining balance in the intestines. It focuses on how intestinal epithelial cells respond to infections or injuries by altering their behavior to promote protective inflammation. The study aims to understand the mechanisms by which these lipids influence the differentiation of intestinal stem cells, particularly during conditions like food allergies and parasitic infections. By exploring these processes, the research seeks to uncover new insights into restoring intestinal health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for managing intestinal inflammation and improving outcomes for patients with food allergies and related conditions.
How similar studies have gone: Previous research has shown promising results in understanding lipid signaling in inflammation, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Tait Wojno, Elia D — University of Washington
- Study coordinator: Tait Wojno, Elia D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.