How a specific lipid affects energy production in cells
PE in modulation of energy flux through OXPHOS
This study is looking at how a special fat called phosphatidyl-ethanolamine helps our cells produce energy, which is important for keeping us healthy, and it could help us understand more about conditions like metabolic disorders and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10896937 on NIH RePORTER |
What this research studies
This research investigates the role of phosphatidyl-ethanolamine (PE), a unique lipid, in regulating energy production within mitochondria, the powerhouses of cells. By examining how PE influences mitochondrial functions, the study aims to understand its impact on ATP synthesis, a crucial energy currency for cellular activities. The researchers will use advanced techniques such as high-resolution respirometry and microscopy to explore how changes in PE levels can affect energy flow and potentially lead to oxidative stress. This work could provide insights into metabolic disorders and cancer biology.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with metabolic disorders or cancers that may be linked to mitochondrial dysfunction.
Not a fit: Patients with conditions unrelated to mitochondrial function or energy metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing energy production in cells, which may benefit patients with metabolic disorders or certain types of cancer.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function and its implications for diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Funai, Katsuhiko — University of Utah
- Study coordinator: Funai, Katsuhiko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.