How a specific immune response affects recovery in older women after a stroke
Official title: Contribution of IL6 trans signaling in older females after ischemic stroke
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11061872 · Data updated 2026-11-12
This study is looking at how a specific immune response affects recovery after a stroke in older women, with the goal of finding ways to help them heal better and improve their movement and thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $622,827 |
| NIH project number | 5R01NS128412-03 |
| Project ID | NIH-11061872 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older females aged 65 and above who have suffered an ischemic stroke.
✕Less likely to help
Patients who are younger than 65 or who have not experienced an ischemic stroke may not benefit from this research.
What this research studies
This research investigates the role of IL6 trans signaling in older females who have experienced an ischemic stroke. It aims to understand how this immune response differs between sexes and how it impacts recovery outcomes. By focusing on the molecular mechanisms involved, particularly the role of microglia and inflammatory responses, the study seeks to identify potential therapeutic targets that could improve recovery for elderly women after a stroke. The research will involve analyzing the effects of IL6 signaling on both motor function and cognitive impairment following stroke.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for older women recovering from strokes, enhancing their long-term functional outcomes.
How similar studies have gone: Previous research has shown that targeting inflammatory pathways can improve recovery outcomes in stroke patients, suggesting that this approach may also be effective in older females.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Chauhan, Anjali — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Chauhan, Anjali
Related research
Other NIH-funded projects on the same topics.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
-
Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
-
Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.