How a specific immune protein affects the body's response to gut parasites
Myeloid derived IL-33 controls Treg responses during parasite infection
This study is looking at a protein called IL-33 to see how it helps or hinders the immune system's response to gut infections, which could lead to better treatments for people dealing with these types of infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11223557 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called IL-33 in the immune response to gastrointestinal parasites. It aims to understand how different sources of IL-33 influence whether the immune response is protective or harmful. By examining how IL-33 affects various immune cells, particularly regulatory T cells, the research seeks to clarify the balance between inflammation and immunosuppression during infections. Patients may benefit from insights into how their immune systems respond to gut infections, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals experiencing gastrointestinal infections or those with immune system disorders.
Not a fit: Patients with non-gastrointestinal infections or those not affected by immune response issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for gastrointestinal infections by enhancing the body's protective immune responses.
How similar studies have performed: Other research has shown promising results in understanding immune responses to infections, suggesting that this approach could yield valuable insights.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Herbert, De'broski R — Tulane University of Louisiana
- Study coordinator: Herbert, De'broski R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.