How a specific gene variant affects immune response in Alzheimer's disease
APOE4 dependent regulation of CSF Complement Pathway Activation in the development of Alzheimer's Disease
This study is looking at how a specific gene called APOE4 might affect the immune system in the brain of people with Alzheimer's disease, and it’s for individuals who carry this gene variant and are willing to share some fluid from their spine for testing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11058400 on NIH RePORTER |
What this research studies
This research investigates the role of the APOE4 gene variant in Alzheimer's disease, particularly how it may influence the immune response in the brain. Researchers will analyze cerebrospinal fluid from individuals carrying the APOE4 allele to assess levels of complement pathway activation, which is linked to the progression of Alzheimer's. By understanding this relationship, the study aims to uncover mechanisms that contribute to the development of Alzheimer's disease. Participants may undergo tests to evaluate their genetic status and provide cerebrospinal fluid samples for analysis.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 60 years old who carry the APOE4 allele.
Not a fit: Patients without the APOE4 allele or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease prevention and treatment strategies for individuals at genetic risk.
How similar studies have performed: Previous research has indicated that understanding genetic factors like APOE4 can significantly impact Alzheimer's disease research, suggesting potential for success in this approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Privratsky, Jamie R — Duke University
- Study coordinator: Privratsky, Jamie R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.