How a specific gene variant affects brain health and sleep in Alzheimer's disease
Impaired Vasoreactivity, Sleep Degradation, and Impaired Clearance in the APOE4 Brain
This study is looking at how a specific gene linked to a higher risk of Alzheimer's affects brain function and sleep, to see how it influences the brain's ability to clear out waste and maintain good sleep quality, and it’s designed for people who want to understand more about their brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11076771 on NIH RePORTER |
What this research studies
This research investigates the impact of the APOE4 gene variant, which is linked to a higher risk of Alzheimer's disease, on brain function and sleep patterns. It aims to understand how this genetic factor influences the brain's ability to clear harmful waste products, particularly during sleep, and how it affects blood flow and sleep quality. By using advanced imaging techniques and monitoring sleep, the study seeks to uncover the mechanisms that contribute to Alzheimer's pathology. Patients may be involved in assessments that help identify these relationships and their implications for brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who carry the APOE4 gene variant and are at risk for Alzheimer's disease.
Not a fit: Patients without the APOE4 gene variant or those who do not have a risk of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving brain health and sleep quality in individuals at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of APOE4 in Alzheimer's disease, indicating that this approach builds on established findings.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Proctor, Elizabeth a — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Proctor, Elizabeth a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.