How a specific gene variant affects asthma treatment in children
Effect of IL-4RαR576 variant on response to Dupilumab in children with Asthma
This study is looking at how a specific gene might affect how well Dupilumab works for kids with asthma, helping us understand why some children respond better to the treatment than others, so we can create more personalized care for them.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10592379 on NIH RePORTER |
What this research studies
This research investigates how the IL-4RαR576 gene variant influences the effectiveness of Dupilumab, a medication used to treat asthma in children. By examining the relationship between this genetic variant and the inflammatory response in the airways, the study aims to better understand why some children with asthma respond differently to treatment. The approach includes analyzing biological samples and patient responses to therapy over time, focusing on those with a mixed TH2/TH17 endotype of asthma. This research could lead to more personalized treatment strategies for young asthma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with asthma, particularly those exhibiting the IL-4RαR576 variant and a mixed TH2/TH17 inflammatory profile.
Not a fit: Patients with asthma who do not have the IL-4RαR576 variant or those with other asthma phenotypes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help identify which children with asthma are most likely to benefit from Dupilumab, leading to more effective and tailored treatments.
How similar studies have performed: Previous research has shown promising results in understanding genetic influences on asthma treatment responses, indicating that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Phipatanakul, Wanda — Boston Children's Hospital
- Study coordinator: Phipatanakul, Wanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.