How a specific gene influences eye development in fruit flies
Specification and patterning of the Drosophila retina by the Pax6 transcription factor
['FUNDING_R01'] · TRUSTEES OF INDIANA UNIVERSITY · NIH-11019148
This study is looking at how certain genes help fruit flies develop their eyes, which could help us understand eye problems in people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TRUSTEES OF INDIANA UNIVERSITY (nih funded) |
| Locations | 1 site (BLOOMINGTON, UNITED STATES) |
| Trial ID | NIH-11019148 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Pax6 transcription factors, Eyeless and Twin of Eyeless, in the formation of the compound eye in fruit flies. By using advanced genetic tools and methods, the researchers aim to understand how these factors contribute to the unique identity of the eye during its early development. The study utilizes the Drosophila model due to its well-defined cellular development processes and the availability of various genetic markers. Insights gained from this research could shed light on congenital eye disorders in humans.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with congenital eye disorders such as aniridia or anophthalmia.
Not a fit: Patients with acquired eye conditions unrelated to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of eye development and potentially lead to new treatments for congenital eye disorders.
How similar studies have performed: Previous research has successfully utilized Drosophila models to understand genetic influences on organ development, indicating a promising approach.
Where this research is happening
BLOOMINGTON, UNITED STATES
- TRUSTEES OF INDIANA UNIVERSITY — BLOOMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUMAR, JUSTIN P — TRUSTEES OF INDIANA UNIVERSITY
- Study coordinator: KUMAR, JUSTIN P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.