How a specific gene affects the sense of smell in Alzheimer's disease.
Cellular and circuit mechanisms underlying APOE-4 effects on olfaction.
This study is looking at how a specific gene linked to Alzheimer's disease affects the sense of smell, which can be one of the first signs of the condition, to help us understand early warning signs and improve ways to diagnose and support people at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-10875722 on NIH RePORTER |
What this research studies
This research investigates how the APOE-4 gene, a major genetic risk factor for Alzheimer's disease, impacts the sense of smell, which is often one of the earliest symptoms of the disease. By studying animal models that express the human APOE-4 gene, researchers aim to understand the underlying neural mechanisms that lead to olfactory deficits before the onset of Alzheimer's pathology. The study focuses on the anterior olfactory nucleus and its connections to other brain regions involved in smell, exploring how imbalances in neural circuits may contribute to early symptoms of Alzheimer's. This research could provide insights into early diagnosis and potential interventions for those at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who carry the APOE-4 allele and may be experiencing early symptoms of Alzheimer's disease.
Not a fit: Patients who do not carry the APOE-4 allele or who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and targeted therapies for individuals at risk of developing Alzheimer's disease.
How similar studies have performed: Previous research has shown that understanding genetic factors like APOE-4 can provide valuable insights into Alzheimer's disease, indicating that this approach has potential for success.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Liu, Shaolin — University of Georgia
- Study coordinator: Liu, Shaolin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.