How a specific gene affects the production of brain cell waste removal particles
Official title: Apolipoprotein E genotype modulates brain mitovesicle production, a component of mitochondrial quality control
Funded at Nathan S. Kline Institute for Psych Res · NIH-10942349 · Data updated 2026-11-12
This study is looking at how a specific gene called APOE affects tiny particles that help keep brain cells healthy by removing waste, and it aims to help people understand how their genetics might influence brain health as they age or deal with neurodegenerative diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nathan S. Kline Institute for Psych Res NIH-funded |
| Lab location | 1 site (Orangeburg, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,499,343 |
| NIH project number | 1RF1AG088226-01 |
| Project ID | NIH-10942349 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with varying APOE genotypes, especially those at risk for Alzheimer's disease.
✕Less likely to help
Patients without any genetic predisposition related to APOE or those with unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates how the APOE genotype influences the production of mitovesicles, which are tiny particles that help remove waste from brain cells and maintain mitochondrial health. By examining the levels and composition of these mitovesicles in relation to different APOE genotypes, the study aims to understand their role in neurodegenerative diseases and aging. Patients may benefit from insights into how their genetic makeup affects brain health and the potential for new therapeutic strategies targeting mitochondrial quality control.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for neurodegenerative diseases, particularly for individuals with specific APOE genotypes.
How similar studies have gone: Previous research has shown promising results in understanding the role of extracellular vesicles in brain health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Nathan S. Kline Institute for Psych Res
Orangeburg, United States Active
Researchers
- Principal investigator: Levy, Efrat — Nathan S. Kline Institute for Psych Res
- Study coordinator: Levy, Efrat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.