How a specific gene affects brain energy supply in Alzheimer's disease
Official title: the contribution of APOE4 mediated bioenergetic deficits in the cerebrovascular dysfunction in Alzheimer's disease
Funded at James a. Haley VA Medical Center · NIH-11061849 · Data updated 2026-11-12
This study is looking at how a specific gene, called APOE E4, might cause problems with energy supply in the brains of people with Alzheimer's disease, and it aims to find ways to help improve brain health and function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James a. Haley VA Medical Center NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 5I01BX006079-02 |
| Project ID | NIH-11061849 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who carry the APOE E4 allele and are experiencing symptoms of Alzheimer's disease.
✕Less likely to help
Patients who do not carry the APOE E4 allele or who have other forms of dementia may not benefit from this research.
What this research studies
This research investigates the role of the APOE E4 gene in causing energy supply issues in the brain, particularly in individuals with Alzheimer's disease. It focuses on how this gene affects the transport of glucose and other nutrients to brain cells, which is crucial for their function. The study will explore the relationship between this genetic factor and cerebrovascular health, aiming to understand how these processes contribute to the progression of Alzheimer's. By examining animal models, the research seeks to identify potential therapeutic targets to improve brain energy metabolism in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving brain health and function in patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of APOE E4 in Alzheimer's, indicating that this approach could yield valuable insights.
Where this research is happening
-
James a. Haley VA Medical Center
Tampa, United States Active
Researchers
- Principal investigator: Abdullah, Laila — James a. Haley VA Medical Center
- Study coordinator: Abdullah, Laila
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.