How a specific gene affects brain development and behavior related to autism
Official title: Epigenetic regulation of the neuroendocrine axis in brain development and behavior
Funded at Creighton University · NIH-11049811 · Data updated 2026-11-12
This study is looking at how a gene called KMT5B affects brain development and behavior, especially in people with autism, to help us understand more about what causes autism and similar conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Creighton University NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | November 15, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $439,804 |
| NIH project number | 1R01MH133600-01A1 |
| Project ID | NIH-11049811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autism spectrum disorder, particularly those with known genetic variants in the KMT5B gene.
✕Less likely to help
Patients without a diagnosis of autism spectrum disorder or those not carrying variants in the KMT5B gene may not benefit from this research.
What this research studies
This research investigates the role of the KMT5B gene in regulating brain development and behavior, particularly in relation to autism spectrum disorder (ASD). By examining how KMT5B influences the expression of insulin-like growth factors in the brain, the study aims to understand the underlying mechanisms of neurodevelopmental disorders. The research will utilize both animal models and human genetic data to explore the effects of KMT5B on gene expression and behavior over time. Patients may benefit from insights gained into the genetic factors contributing to ASD and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential new treatments for autism spectrum disorder.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of autism through similar approaches, suggesting potential for success in this study.
Where this research is happening
-
Creighton University
Omaha, United States Active
Researchers
- Principal investigator: Feser Stessman, Holly Annette — Creighton University
- Study coordinator: Feser Stessman, Holly Annette
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.