How a specific gene affects blood vessel health and diseases
Official title: The transcriptional regulation of smooth muscle genes by PRDM6 in vascular health and diseases
Funded at Yale University · NIH-10999388 · Data updated 2026-11-12
This study is looking at how a gene called PRDM6 affects the smooth muscle cells in your blood vessels, which is important for keeping your heart and blood vessels healthy, and it hopes to find new ways to help prevent heart-related issues like aneurysms and artery hardening.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | December 11, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $753,378 |
| NIH project number | 5R01HL171054-02 |
| Project ID | NIH-10999388 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cardiovascular conditions such as aortic aneurysms, atherosclerosis, or related vascular diseases.
✕Less likely to help
Patients without any cardiovascular conditions or those with unrelated health issues may not benefit from this research.
What this research studies
This research investigates the role of the PRDM6 gene in regulating smooth muscle cells in blood vessels, which are crucial for maintaining vascular health. By examining how this gene influences the behavior of these cells, the research aims to uncover mechanisms that lead to various cardiovascular diseases, such as aortic aneurysms and atherosclerosis. The study employs advanced techniques like high throughput reporter assays and genome-wide association data to identify regulatory elements that control PRDM6 expression. Understanding these processes could lead to new therapeutic strategies for managing vascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for cardiovascular diseases that currently have no cure.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation in vascular health, indicating potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Mani, Arya — Yale University
- Study coordinator: Mani, Arya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.