How a specific gene affects blood vessel cells in Alzheimer's disease
Official title: Impact of APOE on endothelial cell proteomes in Alzheimer's disease
Funded at Emory University · NIH-10889914 · Data updated 2026-11-12
This study is looking at how a specific gene called APOE4 affects blood vessels in the brains of people with Alzheimer's, to help us understand how it might contribute to the disease and improve brain health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $83,392 |
| NIH project number | 5F32AG081135-02 |
| Project ID | NIH-10889914 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those who carry the APOE4 allele.
✕Less likely to help
Patients without Alzheimer's disease or those who do not carry the APOE4 allele may not benefit from this research.
What this research studies
This research investigates the role of the APOE4 gene in Alzheimer's disease, particularly how it influences the proteins in endothelial cells, which line blood vessels in the brain. By analyzing blood vessels from the brains of Alzheimer's patients, the study aims to understand how APOE4 affects the blood-brain barrier and contributes to the disease's progression. The researchers will use advanced techniques to isolate and examine these cells, providing insights into the molecular changes associated with Alzheimer's. This could lead to a better understanding of how genetic factors influence brain health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the mechanisms influenced by the APOE4 gene.
How similar studies have gone: Previous research has shown promising results in understanding the role of APOE in Alzheimer's, but this specific approach focusing on endothelial cell proteomes is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Wojtas, Aleksandra Maria — Emory University
- Study coordinator: Wojtas, Aleksandra Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.