How a specific enzyme affects colon cancer growth and spread
ALOX15 regulation of colon cancer invasiveness via PI3P-linoleic acid metabolism
This study is looking at how a specific enzyme and a type of fat in our diet might affect the growth of colon cancer, with the goal of finding ways to help prevent or lessen the impact of the disease for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10993620 on NIH RePORTER |
What this research studies
This research investigates the role of the ALOX15 enzyme in regulating the invasiveness of colon cancer, particularly focusing on how dietary linoleic acid influences cancer progression. The study examines genetic mutations that contribute to colon cancer and explores how high levels of linoleic acid can promote tumor growth through specific cellular pathways. By understanding these mechanisms, the research aims to identify potential interventions that could prevent or reduce the severity of colon cancer in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of colorectal cancer or those with genetic mutations associated with increased cancer risk, such as APC or KRAS mutations.
Not a fit: Patients without any genetic predisposition to colorectal cancer or those who do not consume diets high in linoleic acid may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations or treatments that help prevent the progression of colon cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of dietary components in cancer progression, suggesting that this approach could yield significant insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Shureiqi, Imad — University of Michigan at Ann Arbor
- Study coordinator: Shureiqi, Imad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.