How a specific cytokine affects heart failure and cardiac fibrosis
Regulation of Cardiac Fibrosis in Heart Failure by the Cytokine FAM3D
This study is looking at a substance called FAM3D to see how it affects heart failure, especially in reducing heart damage and inflammation, and it aims to find new ways to help people with heart problems feel better.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11034204 on NIH RePORTER |
What this research studies
This research investigates the role of the cytokine FAM3D in heart failure, particularly how it influences cardiac fibrosis and inflammation. The study will involve both human plasma samples and animal models to understand the molecular mechanisms behind heart failure and the potential benefits of FAM3D in promoting cardiac health. By examining how FAM3D can limit heart damage and improve heart function, the research aims to uncover new therapeutic targets for heart failure treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing heart failure, particularly those with a history of cardiac events.
Not a fit: Patients with heart failure due to non-inflammatory causes or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce hospitalization rates for patients with heart failure.
How similar studies have performed: Previous research has shown promising results with similar cytokine studies in heart failure, indicating potential for success in this approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Rhee, James — Massachusetts General Hospital
- Study coordinator: Rhee, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.