How a specific bacterium affects gum disease and immune response
Regulation and impact of lipid A modification in the pathogenesis of Porphyromonas gingivalis
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10837092
This study is looking at how a specific bacteria related to gum disease changes itself to avoid being attacked by our immune system, which could help us find better ways to prevent or treat gum problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10837092 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Porphyromonas gingivalis, a bacterium linked to gum disease, in modifying its lipid A structure to evade the immune system. By studying how this bacterium survives in inflammatory conditions and its impact on dental plaque, the research aims to uncover the genetic mechanisms behind its pathogenicity. The team will analyze gene expression in both healthy and diseased gum tissues to understand how environmental factors influence these genes. This could lead to new insights into preventing or treating periodontal disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing gum disease or those with a history of periodontal issues.
Not a fit: Patients with healthy gums and no history of periodontal disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating gum disease, benefiting patients with periodontal issues.
How similar studies have performed: Previous research has shown that understanding bacterial mechanisms in periodontal disease can lead to significant advancements in treatment, indicating a promising avenue for this investigation.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAIN, SUMITA — UNIVERSITY OF WASHINGTON
- Study coordinator: JAIN, SUMITA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.