How a specific bacteria alters immune cell responses
Macrophage Immunosuppression by Quorum-Induced Streptococcus pyogenes
This study is looking at how a type of bacteria called Streptococcus pyogenes affects the way our immune cells, like macrophages, react to infections, with the hope of finding new ways to help our bodies fight off these infections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10852898 on NIH RePORTER |
What this research studies
This research investigates how the bacteria Streptococcus pyogenes can change the way immune cells, specifically macrophages, respond to infections. By examining the bacteria's quorum sensing system, the study aims to understand how it suppresses macrophage activation, which is crucial for fighting infections. The researchers will analyze the interactions between the bacteria and immune cells, focusing on changes in gene expression and cytokine production. This could provide insights into new therapeutic strategies for managing infections and immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with infections caused by Streptococcus pyogenes or those with compromised immune responses.
Not a fit: Patients with infections caused by other types of bacteria or those without immune system involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response against bacterial infections.
How similar studies have performed: Other research has shown promising results in understanding bacterial interactions with the immune system, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Federle, Michael J — University of Illinois at Chicago
- Study coordinator: Federle, Michael J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.