How a single hydride affects enzyme structure and function
The global regulation of dynamics and structure mediated by single hydride in a family of reductases
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-10876397
This study is looking at how a special molecule can change the way certain enzymes work, which are important for turning biliverdin into bilirubin in our bodies, helping us understand how these enzymes are controlled and how they affect our health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10876397 on ClinicalTrials.gov |
What this research studies
This research investigates how a single hydride can induce significant changes in the structure and dynamics of a family of enzymes known as NADPH-dependent reductases. By examining the relationship between coenzyme binding and enzyme function, the study aims to uncover how these changes impact cellular processes, particularly the reduction of biliverdin to bilirubin. The researchers will explore both direct and distal effects of hydride coupling on enzyme activity, providing insights into the fundamental mechanisms of enzyme regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic alterations affecting enzyme function, particularly those related to bilirubin metabolism.
Not a fit: Patients with conditions unrelated to enzyme function or redox processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions related to enzyme dysfunction and redox regulation.
How similar studies have performed: Previous research has shown promising results in understanding enzyme dynamics and regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EISENMESSER, ELAN Z — UNIVERSITY OF COLORADO DENVER
- Study coordinator: EISENMESSER, ELAN Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.