How a single exercise session helps muscles clear blood sugar
Regulation of Elevated Postexercise Insulin-stimulated Glucose Uptake by Skeletal Muscle
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11077312
This project looks at how one bout of exercise helps muscles pull sugar out of the blood better in people with type 2 diabetes or prediabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11077312 on ClinicalTrials.gov |
What this research studies
From a patient perspective, the team is using animal models and gene tools to learn why exercise improves insulin-driven sugar uptake in muscle. They use rats missing a protein called AS160 and deliver genes with adeno-associated virus (AAV) vectors to test which Rab proteins work with AS160. Muscles from both sedentary and exercised rats will be compared to see which molecular steps change after exercise. The research aims to map the cellular signals that allow exercise to boost insulin action in skeletal muscle.
Who could benefit from this research
Good fit: Adults with type 2 diabetes or prediabetes who are interested in exercise-related treatments or future clinical trials would be the most likely candidates to benefit.
Not a fit: People with type 1 diabetes, children, or those whose blood sugar problems are not related to muscle insulin resistance are unlikely to receive direct benefit from this work.
Why it matters
Potential benefit: If successful, this could point to new drugs or therapies that mimic exercise’s effect and help people with type 2 diabetes control blood sugar better.
How similar studies have performed: Prior studies show exercise increases muscle glucose uptake and that AS160 plays a key role in animal models, but pinpointing the specific Rab proteins in real muscle is a newer and less-tested step.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARTEE, GREGORY D. — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: CARTEE, GREGORY D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus