How a retrovirus affects antibody responses in the immune system
Manipulation of antibody responses by a retrovirus
['FUNDING_R21'] · UNIVERSITY OF CHICAGO · NIH-11034374
This study is looking at how a virus affects certain immune cells called B cells, which help your body fight infections, to find ways to boost your immune response and improve how your body makes antibodies when you're sick.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11034374 on ClinicalTrials.gov |
What this research studies
This research investigates how a specific retrovirus, known as the mouse mammary tumor virus, influences the behavior of B cells, which are crucial for producing antibodies that fight infections. By examining how these B cells differentiate into plasma cells and memory B cells, the study aims to understand the mechanisms pathogens use to evade the immune response. The research employs a combination of genetic and immunological techniques to explore the interactions between the virus and the immune system, particularly focusing on antibody production and regulation. Patients may benefit from insights gained about improving antibody responses during infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that compromise their immune response or those who are at risk for infections.
Not a fit: Patients with fully functioning immune systems and no history of recurrent infections may not receive significant benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to enhanced strategies for boosting antibody responses in patients, improving their ability to fight infections.
How similar studies have performed: Other research has shown success in manipulating immune responses through similar approaches, indicating potential for breakthroughs in this area.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLOVKINA, TATYANA V — UNIVERSITY OF CHICAGO
- Study coordinator: GOLOVKINA, TATYANA V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection