How a region of Factor V controls blood clotting balance
Structural Correlates of (Pro)Cofactor Function
Researchers are mapping how a region of the blood protein Factor V controls both clotting and anti-clotting to help people with bleeding or clotting disorders.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11193788 on NIH RePORTER |
What this research studies
This project focuses on the B-domain, a central piece of Factor V that appears to switch it between promoting clots and helping to stop clotting. The team will use high-resolution imaging (atomic force microscopy) and lab experiments to reveal the B-domain's shape and how enzyme cutting changes it. They will also test how Factor V works with natural anticoagulants like APC and TFPIα to understand the balance that prevents bleeding or dangerous clots. Patients can expect this work to inform future tests or treatments rather than provide immediate clinical therapies.
Who could benefit from this research
Good fit: People with known Factor V–related bleeding problems, unexplained bleeding, or a history of abnormal clotting may be most relevant for sample donation or future clinical efforts.
Not a fit: People without clotting disorders or with conditions unrelated to Factor V are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this work could point to new ways to diagnose or treat people at risk of bleeding or dangerous clots.
How similar studies have performed: Previous biochemical and genetic studies have suggested the B-domain influences Factor V function, but detailed structural mapping with techniques like atomic force microscopy is relatively new and not yet translated into treatments.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Camire, Rodney M — Children's Hosp of Philadelphia
- Study coordinator: Camire, Rodney M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.