How a protein in the gut affects bone health
Role of GI OSTERIX in Gut and Bone Biology
['FUNDING_R21'] · RHODE ISLAND HOSPITAL · NIH-10388883
This study is looking at a protein called OSTERIX to see how it affects both gut health and bone health, helping us understand how the two are connected and what that might mean for people with bone issues.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RHODE ISLAND HOSPITAL (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-10388883 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called OSTERIX, which is known for its importance in bone development, in the gastrointestinal (GI) system. The study aims to understand how OSTERIX influences the growth and function of cells in the gut and its potential impact on bone health. By examining the relationship between gut and bone biology, the researchers will explore how OSTERIX affects the balance between bone formation and degradation. This could lead to new insights into how gut health is linked to bone health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting bone health or gastrointestinal function.
Not a fit: Patients with no bone health issues or gastrointestinal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving bone health and preventing bone-related diseases.
How similar studies have performed: While the specific role of OSTERIX in the gut is novel, previous research has shown that gut health significantly impacts bone health, suggesting potential for success.
Where this research is happening
PROVIDENCE, UNITED STATES
- RHODE ISLAND HOSPITAL — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, WENTIAN — RHODE ISLAND HOSPITAL
- Study coordinator: YANG, WENTIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.