How a protein in muscle affects metabolism and exercise
Official title: Role of skeletal muscle IPMK in nutrient metabolism and exercise
Funded at Johns Hopkins University · NIH-11021024 · Data updated 2026-11-12
This study is looking at how a protein called IPMK in your muscles affects how your body uses nutrients and performs during exercise, using mice to help understand its role in energy balance and metabolism, which could lead to better insights for people interested in improving their fitness and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $503,875 |
| NIH project number | 5R01DK135751-03 |
| Project ID | NIH-11021024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may have metabolic disorders or are interested in improving their exercise performance.
✕Less likely to help
Patients with severe muscle diseases or those unable to participate in exercise may not benefit from this research.
What this research studies
This research investigates the role of inositol polyphosphate multikinase (IPMK) in skeletal muscle and its impact on nutrient metabolism and exercise performance. By using mouse models, the study aims to understand how IPMK influences energy homeostasis, glucose tolerance, and overall metabolic health. The researchers will explore how exercise affects IPMK levels and how its absence in muscle cells leads to metabolic disruptions. This could provide insights into the biological mechanisms that regulate metabolism and exercise capacity.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving metabolic health and exercise performance in individuals.
How similar studies have gone: Previous research has shown promising results in understanding the role of IPMK in cellular models, but this specific investigation into skeletal muscle is novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Ahima, Rexford S. — Johns Hopkins University
- Study coordinator: Ahima, Rexford S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.