How a protein helps protect neurons from stress
Neuroprotection by a Secreted Component of the Cellular Stress Response
This study is looking at a special protein that brain cells release when they're under stress to see if it helps keep them healthy, and it's aimed at finding new ways to protect brain cells in people who might be facing similar challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11004282 on NIH RePORTER |
What this research studies
This research investigates a protein secreted by neurons that may protect them during stressful conditions. The study focuses on a specific protein derived from the CREB3L2 transcription factor, which is released when neurons experience stress. Researchers will expose rat cortical neurons to various stressors and analyze how this protein influences neuronal health and signaling pathways. By understanding the mechanisms behind this protective response, the research aims to uncover potential therapeutic strategies for neuroprotection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for neurodegenerative conditions or those experiencing neurological stress.
Not a fit: Patients with acute neurological injuries or those not experiencing stress-related neuronal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance neuronal resilience and protect against neurodegenerative diseases.
How similar studies have performed: Other research has shown promise in using secreted proteins for neuroprotection, indicating that this approach may lead to significant advancements.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Hengst, Ulrich — Columbia University Health Sciences
- Study coordinator: Hengst, Ulrich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.