How a protein helps lung immune cells maintain fluid balance and repair tissue after injury
CREB Instruction of Macrophage Fate and Lung fluid homeostasis
['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10862701
This study is looking at how a protein called CREB helps immune cells in the lungs, called macrophages, do their job in keeping the lungs healthy and repairing them after injuries, which could be helpful for people recovering from lung problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10862701 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific protein, CREB, in guiding the behavior of immune cells called macrophages in the lungs. It focuses on understanding how these cells contribute to maintaining fluid balance and repairing lung tissue after injuries like acute lung injury. By studying genetically modified mice, the researchers aim to uncover the mechanisms that lead to effective tissue repair and fluid homeostasis. This could involve analyzing gene expression and cellular behavior in response to various challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced acute lung injury or other severe lung conditions.
Not a fit: Patients with chronic lung diseases that do not involve acute injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung recovery and fluid balance in patients with severe lung injuries.
How similar studies have performed: Other research has shown promising results in understanding macrophage behavior in lung injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MEHTA, DOLLY — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: MEHTA, DOLLY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.