How a protein helps cells manage iron levels and cell death
The role of NCOA4-mediated ferritinophagy in iron homeostasis and ferroptosis
This study is looking at how a protein called NCOA4 helps control iron levels in cells and how this affects a specific type of cell death that can be important in diseases like cancer, so that patients can better understand how managing iron might influence their treatment and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10819482 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called NCOA4 in managing iron levels within cells and its impact on a type of cell death known as ferroptosis. By understanding how NCOA4 facilitates the breakdown of ferritin, a protein that stores iron, the research aims to clarify how cells release iron when needed and how this process affects cell health. The study employs advanced techniques to observe these cellular mechanisms, which could have implications for various diseases, particularly cancers. Patients may benefit from insights into how iron regulation affects tumor growth and treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with malignancies or conditions related to iron metabolism.
Not a fit: Patients with conditions unrelated to iron homeostasis or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers by targeting iron metabolism.
How similar studies have performed: Other research has shown promising results in understanding iron metabolism in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Mancias, Joseph D — Dana-Farber Cancer Inst
- Study coordinator: Mancias, Joseph D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.