How a protein from fat tissue affects blood pressure rhythms
Official title: Adipose-derived sPRR controls circadian rhythm of blood pressure through inhibition of renal NCC activity
Funded at University of Utah · NIH-10884179 · Data updated 2026-11-12
This study is looking at how a protein from fat tissue affects blood pressure and how your body gets rid of sodium, which could help us find better ways to manage high blood pressure, especially at night.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $574,827 |
| NIH project number | 5R01HL160020-03 |
| Project ID | NIH-10884179 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing issues with blood pressure regulation, particularly those with nocturnal hypertension.
✕Less likely to help
Patients with stable blood pressure and no history of cardiovascular issues may not benefit from this research.
What this research studies
This research investigates how a protein derived from adipose tissue, known as soluble (pro)rein receptor (sPRR), influences the daily patterns of blood pressure and sodium excretion. The study focuses on the role of sPRR in regulating the activity of a sodium transporter in the kidneys, which is crucial for maintaining normal blood pressure rhythms. By examining the interactions between sPRR and specific receptors, the research aims to understand how disruptions in these processes can lead to conditions like nocturnal hypertension, which is linked to cardiovascular diseases. Patients may benefit from insights that could lead to new treatments for managing blood pressure more effectively.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing blood pressure and reducing the risk of cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of circadian rhythms in blood pressure regulation, suggesting that this approach may yield significant insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Yang, Tianxin — University of Utah
- Study coordinator: Yang, Tianxin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.