How a protein complex regulates gene expression and cellular functions
Official title: Post-transcriptional gene regulation by the exon junction complex
Funded at Ohio State University · NIH-11057508 · Data updated 2026-11-12
This study is looking at how a special protein complex helps control gene activity in our cells, which is important for development and can affect conditions like autism and intellectual disabilities, and it's for anyone interested in understanding how our genes work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $341,175 |
| NIH project number | 5R35GM149298-03 |
| Project ID | NIH-11057508 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations linked to developmental disorders, particularly those related to autism spectrum disorder.
✕Less likely to help
Patients without genetic mutations affecting gene regulation or those with unrelated conditions may not benefit from this research.
What this research studies
This research investigates the role of the exon junction complex (EJC) in regulating gene expression through a process called Nonsense-Mediated mRNA Decay (NMD). By studying how EJC interacts with mRNA in human cells and zebrafish embryos, the researchers aim to uncover mechanisms that control cellular functions and responses, particularly in relation to developmental processes and diseases. The study employs a variety of techniques, including genetic and biochemical methods, to explore how disruptions in this regulation can lead to conditions like autism and intellectual disabilities.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for conditions associated with gene regulation disorders, such as autism spectrum disorder.
How similar studies have gone: Previous research has shown that understanding mRNA surveillance pathways can lead to significant advancements in treating genetic disorders, indicating a promising avenue for this study.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Singh, Guramrit — Ohio State University
- Study coordinator: Singh, Guramrit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.