How a protein called Raver1 affects cell death and inflammation
Official title: RNA splicing factor Raver1 controls cell death, inflammation, and innateimmunity
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11141912 · Data updated 2026-11-12
This study is looking at how a protein called Raver1 affects cell death and inflammation, which are important in many diseases, to help find better treatments for conditions where these processes go wrong, especially during bacterial infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | July 19, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $835,485 |
| NIH project number | 5R01AI181309-02 |
| Project ID | NIH-11141912 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions characterized by abnormal cell death or inflammation, such as autoimmune diseases or infections.
✕Less likely to help
Patients with stable conditions that do not involve inflammation or cell death dysregulation may not benefit from this research.
What this research studies
This research investigates the role of the Raver1 protein in regulating cell death and inflammation, which are crucial processes in various diseases. By using advanced techniques like CRISPR/Cas9, the study aims to identify how Raver1 and other splicing factors influence the pathways that lead to cell death, particularly in response to bacterial infections. The findings could help clarify the mechanisms behind these processes, potentially leading to new treatment strategies for conditions where cell death is improperly regulated.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases linked to dysregulated cell death and inflammation.
How similar studies have gone: Previous research has shown promise in understanding cell death pathways, but the specific role of Raver1 in this context is relatively novel and untested.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Lien, Egil — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Lien, Egil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.