How a protein called PON3 affects kidney function and blood pressure
Role of PON3 in regulating renal Na+ and K+ homeostasis
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11145146
This research explores how a protein called PON3 helps control salt and potassium balance in the kidneys, which can affect blood pressure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11145146 on ClinicalTrials.gov |
What this research studies
Our kidneys play a vital role in managing the body's salt and potassium levels, which directly impacts blood pressure. This project focuses on a specific protein, PON3, found in the kidney's salt-sensitive areas. We believe PON3 helps regulate how much salt the body keeps or releases by influencing a key channel called ENaC. Understanding PON3's role could reveal new ways to manage blood pressure and kidney health.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies based on this work might seek individuals with high blood pressure or kidney issues related to salt and potassium regulation.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and potentially treat conditions related to blood pressure and kidney salt imbalance.
How similar studies have performed: While the specific role of PON3 in blood pressure is new, other members of the PON family have been linked to blood pressure regulation, suggesting a plausible connection.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHI, SHUJIE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: SHI, SHUJIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.